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Synthetic Biology (SynBio) has become a rapidly developing area for tackling a large number of challenges in life science research. This is due to a combination of foundational advances in technologies, such as large-scale DNA synthesis and new methods that allow integrating such raw synthesis power into engineering approaches. Those include genome wide small RNA regulation, dCas9-based regulation, and multiplexed genome engineering. Such fresh approaches fuel new types of biotechnological applications with immense impact on both fundamental science and society.