Research

Research and innovation for environmental solutions deployment.

EBIC is embarking on an exciting research journey aimed at addressing urgent environmental challenges. The centre’s focus is on using cutting-edge techniques from synthetic biology, biotechnology, computation modelling and engineering science to develop innovative solutions in bioengineering and bioremediation. Through genetic engineering, researchers can modify the genetic material of organisms, making them more effective at removing specific pollutants from the environment. This includes targeting substances like plastic waste, hydrocarbons, and metals. By enhancing the natural abilities of these organisms, we can find more sustainable and cost-effective ways to clean up our planet.

Another aspect of the research to be performed under EBIC involves metabolic engineering, where chemical pathways inside organisms can be modified. By introducing new enzymes or optimizing existing ones, “microbial factories” that efficiently break down harmful chemicals can be created. This helps in the safe disposal of pollutants and contributes to a cleaner environment.

EBIC’s research will also explore the development of biosensors and biodevices that can detect and respond to environmental pollutants in real- time. These devices act as environmental monitors, allowing us to identify and address issues promptly. This rapid response helps in protecting ecosystems and human health. Additionally, we are using advanced genome editing technologies to precisely modify the DNA of organisms. This allows the development of entirely new organisms or enhance the functions of existing ones. By doing so, organisms that are better suited for environmental tasks can be designed like converting waste into valuable resources.

Effective addressal of environmental pollution necessitates a focus on research and innovation that yields readily deployable solutions. A promising approach is the integration of Synbio with environmental biotechnologies targeting specific pollution sources such as municipal wastewater and industrial effluents. Key to finding effective solutions are advances in biological detection and reporting, engineering enzymes for targeted degradation, and enhancing biosystem resilience.

EBIC plans to leverage expertise and technologies through four defined technical pillars:

Engineering DNA

Aims to develop rapid plasmid assembly systems for engineering environmentally relevant microbes. Modular cloning suites will be adapted to facilitate efficient plasmid assembly, incorporating CRISPR-Cas9 systems, selectable markers, and promoters/terminators for precise gene expression. This will enable precise genetic modifications in a range of bacteria.

Biomolecular Engineering

Focuses on manipulating individual biomolecules to achieve enhanced functionalities. It involves producing functional macromolecules using natural and synthetic components and designing intricate circuits and pathways. The goal is to engineer biomolecules to meet specific functional requirements and explore a wide range of applications.

Host and Consortia Engineering

Aims to develop robust and flexible synthetic biology systems for diverse biochemical reactions. This includes adapting single-cell hosts, engineering traits in multicellular organisms, and manipulating microbial consortia. Overcoming challenges related to biofilm formation, stability, scalability, and pollutant capture is essential for successful application in wastewater and waste treatments.

The Data Science/Mind Map System Biology

Integrates data science, modelling, artificial intelligence, and automation to support the design, build, test, learn (DBTL) methodology. It involves developing computational infrastructure for predicting design outcomes, optimising manufacturing processes, and integrating diverse datasets using specialised software suites, such as Infobiotics Workbench, Synbiotics, and NUFEB, facilitate computer-aided design for the simulation of microbial communities, and metabolic engineering.